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"LRG_299p1:p.Val600Glu", "NG_007873.3:g.176429T>A", "ENSP00000288602.6:p.Val600Glu", "P15056:p.V600E", "XP_005250103.1:p.Val600Glu", "XP_005250102.1:p.Val600Glu", "ENSP00000418033.1:p.V28E", "XP_005250102.1:p.V600E", "XP_005250103.1:p.V600E", "XP_011514831.1:p.V600E", "NP_001341538.1:p.Val600Glu", "NC_000007.14:g.140753336A>T", "XP_011514832.1:p.=", "XP_016868047.1:p.Val640Glu", "chr7:g.140453136A>T", "ENSP00000418033.1:p.Val28Glu", "CM000669.2:g.140753336A>T" ], "hgvs_g_suffix": [ "g.140099605A>T", "g.140453136A>T", "g.140753336A>T", "g.176429T>A" ], "hgvs_p_suffix": [ "p.Val600Glu", "p.V640E", "p.V600E", "p.=", "p.V28E", "p.Val28Glu", "p.Val640Glu" ], "links": [ "http://reg.genome.network/refseq/RS000031", "http://reg.genome.network/refseq/RS000055", "http://myvariant.info/v1/variant/chr7:g.140453136A>T?assembly=hg19", "http://gnomad.broadinstitute.org/variant/7-140453136-A-T", "http://myvariant.info/v1/variant/chr7:g.140753336A>T?assembly=hg38", "http://reg.genome.network/allele/CA123643", "http://reg.genome.network/refseq/RS000007", "http://www.ncbi.nlm.nih.gov/snp/113488022", "http://www.ncbi.nlm.nih.gov/clinvar/variation/13961", "http://www.ncbi.nlm.nih.gov/clinvar/?term=29000[alleleid]", "http://cancer.sanger.ac.uk/cosmic/mutation/overview?id=476", "http://exac.broadinstitute.org/variant/7-140453136-A-T", "http://reg.genome.network/refseq/RS000682" ], "name": "V600E", "provenance": [ "http://reg.genome.network/allele?hgvs=NC_000007.13%3Ag.140453136A%3ET" ], "provenance_rule": "from_source", "ref": "A", "referenceName": "GRCh37", "start": 140453136, "synonyms": [ "NP_004324.2:p.Val600Glu", "XM_017012559.1:c.1919T>A", "XM_005250046.1:c.1799T>A", "XM_011516530.1:c.1695-3918T>A", "XP_011514831.1:p.Val600Glu", "XM_005250045.1:c.1799T>A", "NR_148928.1:n.2897T>A", "LRG_299:g.176429T>A", "NM_004333.4:c.1799T>A", "NC_000007.12:g.140099605A>T", "XP_011514832.1:p.=", "CM000669.1:g.140453136A>T", "XP_016868048.1:p.Val640Glu", 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"SL.AO9chSP6yzDTKDrP9W1FNG3vzrQFxiDg", "SQ.WaAJ_cXXn9YpMNfhcq9lnzIvaB9ALawo", "VA.u6sKlz0mMQvARmrlnt0Aksz6EbSkmL8z", "SL.gJeEs42k4qeXOKy9CJ515c0v2HTu8s4K", "VA.wR8qEkdmZzqhNYsKpdfLdfWHsZJf9Oe0", "SL.mHP-jIvDKOG6r-mhkhgNNrtHXa2clUSK", "SL.DZoooeFERHEJblsB0_NmHlXpdphuVujm", "VA.xVnu44bpUnozgoA0G7r-RfX48cLVCB_o" ], "gene_identifiers": [ { "ensembl_gene_id": "ENSG00000157764", "entrez_id": "673", "symbol": "BRAF" } ], "genes": [ "BRAF" ], "publications": "http://www.ncbi.nlm.nih.gov/pubmed/27297867", "response": "sensitive", "source": "jax", "source_url": "https://ckb.jax.org/therapy/show/4604", "tags": [], "text_object": { "definition": "BRAF V600E", "id": "ga4gh:VT.9Wer7KrxALcPRDRGVKOEzf9ZEKZpOKK0", "type": "Text" } }, { "association": { "description": "In a clinical case report, Tafinlar (dabrafenib) and Mekinist (trametinib) combination treatment resulted in a clinical and radiologic response that lasted for 9 months in an anaplastic thyroid cancer patient harboring BRAF V600E (PMID: 27697975).", "disease_labels_truncated": "thyroid cancer", "drug_labels": "DABRAFENIB,TRAMETINIB", "drug_labels_truncated": "DABRAFENIB", "environmentalContexts": [ { "approved_countries": [ "Canada", "US" ], "description": "DABRAFENIB", "id": "44462760", "source": "http://rdf.ncbi.nlm.nih.gov/pubchem/compound", "taxonomy": { "class": "Benzene and substituted derivatives", "direct-parent": "Sulfanilides", "kingdom": "Organic compounds", "subclass": "Sulfanilides", "superclass": "Benzenoids" }, "term": "DABRAFENIB", "toxicity": "LD50 in rats is > 2000 mg/kg [MSDS].\r\n\r\n\r\nThe most common side effects of Daretinib (Tafinlar) as a single agent include: hyperkeratosis, headache, pyrexia, arthralgia, papilloma, alopecia, and palmar-plantar erythrodysesthesia syndrome [FDA label].\r\n\r\nThe most common adverse reactions (\u226520%) for Tafinlar in combination with [DB08911] are pyrexia, chills, fatigue, rash, nausea, vomiting, diarrhea, abdominal pain, peripheral edema, cough, headache, arthralgia, night sweats, decreased appetite, constipation, and myalgia [FDA label].\r\n\r\nThe following is a list of toxicities that may occur with the combination of Daretinib and [DB08911]:\r\n\r\n**New primary malignancies**: These may occur when Tafinlar is administered as a single agent or in combination with [DB08911]. Monitor patients for new malignancies prior to initiation of therapy, while on therapy, and following discontinuation of TAFINLAR or the combination therapy. Tumor Promotion in BRAF Wild-Type Melanoma: Increased cell proliferation can occur with BRAF inhibitors [FDA label].\r\n\r\n**Hemorrhage:** Major hemorrhagic events can occur in patients receiving TAFINLAR in combination with trametinib. Monitor for signs and symptoms of bleeding [FDA label]. \r\n\r\n**Venous Thromboembolism**: Deep vein thrombosis and pulmonary embolism can occur in patients receiving the drug combination [FDA label].\r\n\r\n**Cardiomyopathy **: Assess LVEF before treatment with TAFINLAR in combination with trametinib, after one month of treatment, then every 2 to 3 months thereafter [FDA label]. \r\n\r\n**Ocular toxicities**: Perform an ophthalmologic evaluation for any visual disturbances [FDA label]. \r\n\r\n**Serious Febrile Reactions:** Incidence and severity of pyrexia are increased with TAFINLAR in combination with trametinib [FDA label]. \r\n\r\n**Serious Skin Toxicity:** Monitor for skin toxicities and for secondary infections. Discontinue for intolerable Grade 2, or Grade 3 or 4 rash not improving within 3 weeks despite the interruption of TAFINLAR [FDA label]. \r\n\r\n**Hyperglycemia:** Monitor serum glucose levels in patients with pre-existing diabetes or hyperglycemia [FDA label]. \r\n\r\n**Glucose-6-Phosphate Dehydrogenase Deficiency**: Closely monitor for hemolytic anemia [FDA label]. \r\n\r\n**Embryofetal Toxicity**: Can cause fetal harm. Advise females of reproductive potential of potential risk to a fetus. TAFINLAR may render hormonal contraceptives less effective and an alternative method of contraception should be used [FDA label].", "usan_stem": "raf kinase inhibitors" }, { "approved_countries": [ "EU", "Canada", "US" ], "description": "TRAMETINIB", "id": "11707110", "source": "http://rdf.ncbi.nlm.nih.gov/pubchem/compound", "taxonomy": { "class": "Pyridopyrimidines", "direct-parent": "Pyridopyrimidines", "kingdom": "Organic compounds", "superclass": "Organoheterocyclic compounds" }, "term": "TRAMETINIB", "toxicity": "Most common adverse reactions (\u226520%) for trametinib include rash, diarrhea, and lymphedema [FDA label].\r\n\r\nThe most common adverse reactions (\u226520%) for Tafinlar in combination with Trametinib are pyrexia, chills, fatigue, rash, nausea, vomiting, diarrhea, abdominal pain, peripheral edema, cough, headache, arthralgia, night sweats, decreased appetite, constipation, and myalgia [FDA Label].\r\n\r\nThe following is a list of toxicities that may occur with the combination of Dabrafenib and Trametinib:\r\n\r\n**New primary malignancies**: These may occur when Tafinlar is administered as a single agent or in combination with Trametinib. Monitor patients for new malignancies prior to initiation of therapy, while on therapy, and following discontinuation of TAFINLAR or the combination therapy. Tumor Promotion in BRAF Wild-Type Melanoma: Increased cell proliferation can occur with BRAF inhibitors [FDA Label].\r\n\r\n**Hemorrhage**: Major hemorrhagic events can occur in patients receiving TAFINLAR in combination with trametinib. Monitor for signs and symptoms of bleeding [FDA Label].\r\n\r\n**Venous Thromboembolism**: Deep vein thrombosis and pulmonary embolism can occur in patients receiving the drug combination [FDA Label].\r\n\r\n**Cardiomyopathy**: Assess LVEF before treatment with TAFINLAR in combination with trametinib, after one month of treatment, then every 2 to 3 months thereafter [FDA Label].\r\n\r\n**Ocular toxicities**: Perform an ophthalmologic evaluation for any visual disturbances [FDA Label].\r\n\r\n**Serious Febrile Reactions**: Incidence and severity of pyrexia are increased with TAFINLAR in combination with trametinib [FDA Label].\r\n\r\n**Serious Skin Toxicity**: Monitor for skin toxicities and for secondary infections. Discontinue for intolerable Grade 2, or Grade 3 or 4 rash not improving within 3 weeks despite the interruption of TAFINLAR [FDA Label].\r\n\r\n**Hyperglycemia**: Monitor serum glucose levels in patients with pre-existing diabetes or hyperglycemia [FDA Label].\r\n\r\n**Glucose-6-Phosphate Dehydrogenase Deficiency**: Closely monitor for hemolytic anemia [FDA Label].\r\n\r\n**Embryofetal Toxicity**: Can cause fetal harm. Advise females of reproductive potential of potential risk to a fetus. TAFINLAR may render hormonal contraceptives less effective and an alternative method of contraception should be used [FDA Label].", "usan_stem": "tyrosine kinase inhibitors: mitogen-activated protein (MAP) kinase inhibitors" } ], "evidence": [ { "description": "sensitive", "evidenceType": { "sourceName": "jax" }, "info": { "publications": [ "http://www.ncbi.nlm.nih.gov/pubmed/27697975" ] } } ], "evidence_label": "C", "evidence_level": 3, "phenotypes": [ { "description": "thyroid cancer", "family": "cancer", "id": "MONDO:0002108", "source": "http://purl.obolibrary.org/obo/MONDO_0002108", "term": "thyroid cancer" } ], "publication_url": "http://www.ncbi.nlm.nih.gov/pubmed/27697975", "response_type": "sensitive", "source_link": "https://ckb.jax.org/molecularProfile/show/1", "variant_name": [ "V600E" ] }, "dev_tags": [], "diseases": "thyroid cancer", "drugs": "DABRAFENIB,TRAMETINIB", "evidence_label": "C", "feature_names": "BRAF V600E", "features": [ { "alt": "T", "chromosome": "7", "end": 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"text_object": { "definition": "BRAF V600E", "id": "ga4gh:VT.9Wer7KrxALcPRDRGVKOEzf9ZEKZpOKK0", "type": "Text" } }, { "association": { "description": "In a preclinical study, TW-37 enhanced the inhibitory effect of Mekinist (trametinib) on human non-small cell lung cancer cells harboring BRAF V600E in culture (PMID: 25665005).", "disease_labels_truncated": "non-small cell lung carcinoma (disease)", "drug_labels": "TRAMETINIB", "drug_labels_truncated": "TRAMETINIB", "environmentalContexts": [ { "approved_countries": [ "EU", "Canada", "US" ], "description": "TRAMETINIB", "id": "11707110", "source": "http://rdf.ncbi.nlm.nih.gov/pubchem/compound", "taxonomy": { "class": "Pyridopyrimidines", "direct-parent": "Pyridopyrimidines", "kingdom": "Organic compounds", "superclass": "Organoheterocyclic compounds" }, "term": "TRAMETINIB", "toxicity": "Most common adverse reactions (\u226520%) for trametinib include rash, diarrhea, and lymphedema [FDA label].\r\n\r\nThe most common adverse reactions 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Monitor patients for new malignancies prior to initiation of therapy, while on therapy, and following discontinuation of TAFINLAR or the combination therapy. Tumor Promotion in BRAF Wild-Type Melanoma: Increased cell proliferation can occur with BRAF inhibitors [FDA Label].\r\n\r\n**Hemorrhage**: Major hemorrhagic events can occur in patients receiving TAFINLAR in combination with trametinib. Monitor for signs and symptoms of bleeding [FDA Label].\r\n\r\n**Venous Thromboembolism**: Deep vein thrombosis and pulmonary embolism can occur in patients receiving the drug combination [FDA Label].\r\n\r\n**Cardiomyopathy**: Assess LVEF before treatment with TAFINLAR in combination with trametinib, after one month of treatment, then every 2 to 3 months thereafter [FDA Label].\r\n\r\n**Ocular toxicities**: Perform an ophthalmologic evaluation for any visual disturbances [FDA Label].\r\n\r\n**Serious Febrile Reactions**: Incidence and severity of pyrexia are increased with TAFINLAR in combination with trametinib [FDA Label].\r\n\r\n**Serious Skin Toxicity**: Monitor for skin toxicities and for secondary infections. Discontinue for intolerable Grade 2, or Grade 3 or 4 rash not improving within 3 weeks despite the interruption of TAFINLAR [FDA Label].\r\n\r\n**Hyperglycemia**: Monitor serum glucose levels in patients with pre-existing diabetes or hyperglycemia [FDA Label].\r\n\r\n**Glucose-6-Phosphate Dehydrogenase Deficiency**: Closely monitor for hemolytic anemia [FDA Label].\r\n\r\n**Embryofetal Toxicity**: Can cause fetal harm. Advise females of reproductive potential of potential risk to a fetus. TAFINLAR may render hormonal contraceptives less effective and an alternative method of contraception should be used [FDA Label].", "usan_stem": "tyrosine kinase inhibitors: mitogen-activated protein (MAP) kinase inhibitors" } ], "evidence": [ { "description": "sensitive", "evidenceType": { "sourceName": "jax" }, "info": { "publications": [ "http://www.ncbi.nlm.nih.gov/pubmed/25665005" ] } } ], "evidence_label": "D", "evidence_level": 4, "phenotypes": [ { "description": "non-small cell lung carcinoma (disease)", "family": "lung carcinoma", "id": "MONDO:0005233", "source": "http://purl.obolibrary.org/obo/MONDO_0005233", "term": "non-small cell lung carcinoma (disease)" } ], "publication_url": "http://www.ncbi.nlm.nih.gov/pubmed/25665005", "response_type": "sensitive", "source_link": "https://ckb.jax.org/molecularProfile/show/1", "variant_name": [ "V600E" ] }, "dev_tags": [], "diseases": "non-small cell lung carcinoma (disease)", "drugs": "TRAMETINIB", "evidence_label": "D", 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